Noor Altaleb* Pages 65 - 77 ( 13 )
Although there are no 100% successful methods for treating cancer, chemotherapy is still one of the most commonly used approaches in its management. One of the most significant problems in cancer treatment is the resistance of cancer cells to chemotherapeutic agents. This review aims to unveil the factors contributing to this problem originally beginning with fundamental units like biomarkers and microRNAs. As more studies and researches carried out, various levels of miRNA expression were found among normal and cancer cells. Overexpression of oncomir and downregulation of tumour-suppressor miRNAs can lead to the emergence of cancer. Data collected from studying these miRNAs can help in the diagnosis, prognosis and developing therapies, which will assist in overcoming the emerged resistance.
Biomarkers, cancer, cobomarsen, mesomir, miRNA, MRX34, resistance, therapy, tumour.
Department of Pharmacology, Faculty of Pharmacy, University of Sharjah, Sharjah