Shinta Oktya Wardhani*, Hani Susianti, Puji Rahayu and Yuyun Yueniwati Pages 119 - 124 ( 6 )
Background: The failure of imatinib therapy in patients with chronic myeloid leukemia (CML) is associated with the presence of leukemic stem cell (LSC), and the altered LSC level was reported to occur earlier in the progression of CML.
Objective: The study aimed to assess the association between the level of LSC and treatment response among CML patients treated with imatinib mesylate.
Methods: A cross-sectional study was conducted in Saiful Anwar Hospital. All participants were divided into two groups, response and non-response group. To assess the level of LSC, flow cytometry was conducted conforming with BD Bioscience. The association and effect estimates were determined using multiple logistic regression.
Results and Discussion: A total of 29 response and non-response CML patients treated with imatinib therapy were recruited for our study. After six months of imatinib therapy, we found that elevated levels of leukocytes, thrombocytes, basophils, and blast cells were associated with treatment failure among CML patients treated with imatinib. Moreover, we also found that the LSC level was observed significantly higher in the non-response group compared to the response group among CML patients treated with imatinib.
Conclusion: Our study reveals that the elevated level of LSC is considered as an important factor to predict the failure of imatinib therapy among CML patients.
Imatinib mesylate, treatment response, chronic myeloid leukemia, stem cells, imatinib therapy, leukocytes.
Doctoral Program, Division of Medical Oncology and Hematology, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Department of Clinical Pathology, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Department of Radiology, Faculty of Medicine, Universitas Brawijaya, Malang, 65145